Guillermo Del Toro and THQ's newest game, inSane, announced to be part of a trilogy of games. It confirms the ending is either going to be a cliff hanger or end in a way that guarantees a sequel.
Seeing as THQ learned nothing from the Too Human fiasco of making a trilogy before getting any critical or consumer feedback, the odds on the series even making to a sequel would be slim.
The first game in the series is set for a 2013 release date.
http://kotaku.com/5712916/uh+oh-guil...e-is-a-trilogy