Since Ock's physical body is dead and Peter will come back eventually, I'm betting Ock will be reborn and maintain as Superior Spidey, giving Marvel four Spidey's to play with along with Scarlet and 2099.
In my Armchair Editor opinion; I'd then have Peter Spidey do his duties in the main Spidey book and return to the Avengers. Scarlet can hook up with the Secret Avengers or whatever. 2009 Spidey can get promoted to cosmic heroism and join the Guardians. Superior Spidey can roll with the Thunderbolts or a similarly themed dark team.
Eventually we can get Arana/Spider-Girl and has a Spider Team story. Just spider people everywhere.
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